If you have setup an email address with Sitelio and wish to send and receive email in Mail for Mac then this article will help.
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Open Mail (Applications > Mail)
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On the Menu bar click Mail > Add Account…
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Choose Add Other Mail Account… and click Continue
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Specify your Full Name as you want others to see it, your Sitelio email address and the email address password and click Next
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Set the Account Type as IMAP
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Input the Mail Server as imap.yourdomain.com
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Enter the full email address in the User Name field
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Enter the email address password and click Next
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Input the SMTP Server as smtp.yourdomain.com
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Enter the full email address in the User Name field
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Enter the email address password and click Create
Your New Mailbox will appear in the sidebar of Mail and now be configured as a mail account within OSX.
Please also find this Apple Support article on configuring email accounts within Mail for Mac.